The key to purging the HIV virus from an organism could actually be a choice of different keys. One is a viricide that doesn't trigger the HIV to mutate. Or it includes a sequence that turns off the mutational phenomena in the virus.
Another is that all human immune systems, with rare exceptions, are damaged by human synthetic environments. Other primates in a natural environment have immunity. There is a possibility that two generations in a natural environment may produce a natural immunity to the HIV virus. The key to immunology, talking about keys, has always been the natural immunity of the organism to be immunized. Once again, here, we're talking about infinite complexities that begin to break down, or be destroyed, in the synthetic environment.
Mutational triggers in a virus, such as the HIV strains are highly complex. It is thought that the virus itself is simple or highly simplified since it depends on a host for the genetic material for reproduction. But this is not the case. Further research will reveal that these cells are highly complex. In fact, it may be found that monocellular organisms are even more complex in their makeup, chemistry, and functionality than those cells that are part of a macro-organism which can depend on teamwork for their subsistence.
As we look beneath the outer membranes of such a cell as the HIV virus organism, we begin to see microscopic engines of all types and functions. Somewhere in this vast array even below microscopic, in the realm of the molecular -- and even in some cases the atomic, you will find functionalities, triggers, molecular tags, and all sorts of apparatuses heretofore unnamed.
In fact , it is arguable that in every cellular structure, from multi-cellular organisms to even the simplest viruses, to -- the unknown, for there may actually be organisms smaller than a virus -- there is the infinite; that each cell is in itself linked in this respect to the cosmos. There may even be organisms that consist of molecules or organic molecules that exist without nuclear reproductive material such as DNA or RNA: That may even have their sequences registered subatomically with quarks or some other infinitesimally small quanta.
If you look into the mechanisms of the cellular structure of the HIV virus, probably just below the outer membranes, there you may find the mechanisms for mutation. In all probability, a good place to start looking is some sort of sensitivity on a molecular scale somewhat like the sensory organs on a macro-organism. Of course thus far I'm stating the obvious.
But I think you will find that this is intriguing here. It may involve a whole new series of processes involving nanotechnology in order to actually, in the first place, dissect the cell and then find ways to observe and record what is actually there. The nanobiological microscope with micro transmitter capability.
Actually in the process of analyzing the virus, there may be discoveries less applicable to the dilemma and yet more interesting, and in fact quite intriguing as to the makeup of this organism. It has always been my supposition that in a primitive way, it is possible to have an "interface", or communication, in a rudimentary sort of way of course, with the organism and all organisms of its type invading any specific host, in which it may be possible to work out an "in host genetic compromise" (not to be confused with the erroneous term, "compromised immune system"), which may end up to be the cure.
In this case, it may turn out to be that the HIV organism itself, that has been enabled to become genetically compromised, may actually serve as a new addition to the macro-organism of the host it occupies. The new "employee" of the organism could then form anywhere from one to many useful functions, such as enhancing the robustness of the host's immune system, or other types of things such as attacking the mechanisms that cause Alzheimer's disease, or helping to repair damage in specialized areas caused by exposure to caustic or toxic materials, such as in the liver or spleen of the host.